Lansoprazole 30 mg and omeprazole 20 mg are, for practical purposes, interchangeable. A meta-analysis of six randomised double-blind trials put 8-week healing rates for erosive oesophagitis at 88.7% for lansoprazole and 87.0% for omeprazole — a difference whose confidence interval comfortably included zero. If someone has switched you from one to …

Lansoprazole for Acid Reflux: How It Compares to Omeprazole Read More

Pantoprazole (Protonix) is a proton pump inhibitor, and the standard adult dose for reflux is 40 mg once daily — taken 30 to 60 minutes before your first meal of the day, not with it and not after. That timing detail is not a nicety. It’s the single most common …

Pantoprazole for Acid Reflux: Dosing, Timing, Side Effects Read More

Ranitidine is gone and it isn’t coming back. On 1 April 2020 the FDA requested that every manufacturer withdraw all prescription and over-the-counter ranitidine from the US market immediately, after testing showed that levels of a probable carcinogen called NDMA rise inside the tablets over time — faster in …

Zantac Recall: What to Take Instead of Ranitidine Read More

Probably not — at least not for the reflux you’re actually dealing with. Pepto-Bismol can take the edge off a one-off bout of overindulgence heartburn, and there are two old randomised trials showing exactly that. But it isn’t an antacid, it doesn’t meaningfully neutralise stomach acid, it doesn’t coat …

Does Pepto-Bismol Help Acid Reflux? (Probably Not) Read More

Prucalopride is the most interesting prokinetic in the reflux conversation right now — and the one with the strangest evidence gap. In healthy volunteers it cut oesophageal acid exposure roughly in half, sped up gastric emptying and improved acid clearance. In gastroparesis patients it beat placebo on both symptoms …

Prucalopride for Acid Reflux: A Prokinetic That Works? Read More